Biosis Healing Membrane
Biological Dental Membrane — by Biosis Healing
Overview
The Biosis Healing Membrane is a biological dental membrane prepared from non-crosslinked extracellular matrix-derived biomaterial (SIS) — decellularized submucosal matrix sourced from porcine small intestine. Unlike synthetic collagen membranes, it retains its natural fibrous porous structure and is rich in bioactive growth factors, collagen, and glycosaminoglycans that actively induce tissue regeneration.
The decellularization process removes immunogenic substances while preserving the bioactive scaffold, providing excellent tissue compatibility and controlled in-body degradation without leaving foreign residues. The membrane promotes rapid vascularization, accelerates mucosal coverage, and induces cell differentiation — supporting faster, more complete healing at the surgical site.
With good malleability and high tissue affinity, it conforms closely to target tissues and can be trimmed chairside to fit any defect geometry. Available in five standardized sizes for single-tooth sites through to larger multi-site applications.
Key Highlights
- SIS extracellular matrix — not synthetic collagen
- Retains natural fibrous porous structure
- Rich in bioactive growth factors for active regeneration
- Rapid vascularization and cell differentiation induction
- Fully resorbable — degrades without foreign residues
- No second surgery required for membrane removal
- Decellularized to remove immunogenic substances
- Excellent biocompatibility and tissue affinity
- Good malleability — conforms closely to defect anatomy
- Five sizes: 15×15 mm to 30×40 mm
- GBR, GTR, socket preservation & ridge augmentation
- Compatible with all bone graft and particulate materials
Features & Clinical Applications
Biologically active regeneration for the full range of implant and periodontal procedures
SIS Extracellular Matrix Material
Derived from decellularized porcine small intestine submucosa (SIS) — a non-crosslinked extracellular matrix biomaterial that retains its natural fibrous porous structure and is rich in bioactive growth factors, collagen, and glycosaminoglycans that actively support tissue regeneration.
Rapid Vascularization
The preserved bioactive matrix induces rapid vascularization at the regeneration site, accelerates mucosal coverage of defects, and stimulates cell differentiation — promoting faster, more complete tissue repair compared to synthetic barriers.
Fully Resorbable — No Second Surgery
Degrades naturally in the body without leaving foreign residues. The controlled resorption releases bioactive factors over the healing period, supporting ongoing tissue regeneration without requiring a second procedure for membrane removal.
Excellent Biocompatibility
Processed through thorough decellularization to remove immunogenic substances, leaving behind a biocompatible scaffold with good tissue affinity. High product compliance and malleability ensure close adhesion to target tissues and easy adaptation to defect geometry.
Guided Bone & Tissue Regeneration
Indicated for GBR and GTR procedures including socket preservation, lateral and vertical ridge augmentation, furcation involvement, peri-implant defects, and periodontal tissue regeneration. Compatible with all bone graft materials and particulate grafts.
Five Standardized Sizes
Available in dimensions from 15×15 mm to 30×40 mm to suit single-tooth sites through to larger multi-site defects. Each membrane can be trimmed chairside for precise fit.
Clinical Literature
Published studies supporting the science behind SIS extracellular matrix membrane technology
Advanced Healthcare Materials
SIS extracellular matrix biomaterial research
Composites Part B — Bone Regeneration
Guided bone regeneration with SIS membrane
Biosis — Guided Bone Regeneration with SIS Scaffold
Extracellular matrix scaffold of small intestinal submucosa
Advanced Functional Materials — Guided Bone Regeneration
Functional materials research on guided bone regeneration
Bone Regeneration
Bone regeneration clinical study
See It in Action
Product overview and clinical demonstration
Product Specifications
| Material | Non-crosslinked porcine small intestine submucosa (SIS) — extracellular matrix biomaterial |
| Appearance | Pale yellow, sheet-like membrane |
| Structure | Natural fibrous porous structure retained post-decellularization |
| Resorbability | Fully resorbable — degrades without foreign residues |
| Bioactive Content | Growth factors, collagen, glycosaminoglycans |
| Regulatory | National Medical Device Registration Approval 20223170457 |
| Manufacturer | Beijing Biosis Healing Biological Technology Co., Ltd. |
Sizes & Pricing
Spring promotion pricing currently in effect
| SKU | Dimensions | Retail Price | Spring Promotion |
|---|---|---|---|
| SIS-ORP-ZL1.5 | 15 mm × 15 mm | $69.00 | $41.40 |
| SIS-ORP-ZL1.5×2.5 | 15 mm × 25 mm | $99.00 | $59.40 |
| SIS-ORP-ZL2×2 | 20 mm × 20 mm | $109.00 | $65.40 |
| SIS-ORP-ZL2×3 | 20 mm × 30 mm | $149.00 | $89.40 |
| SIS-ORP-ZL4×3 | 30 mm × 40 mm | $239.00 | $143.40 |
Contact us for bulk orders
Order Biosis Healing Membranes
Contact our team to order any size or discuss bulk pricing for your practice or clinic.